Linotype FontExplorer X is my new favorite program. This is the font management program that should have always been. At first glance it's a direct copy of iTunes, enough so that I wonder if they paid Apple any licensing fees. It even includes a store to purchase new fonts. After using it a while I can really appreciate the time they spent thinking over the details beyond the iTunes model. Font management is a little more complicated, but they kept it easy to use, and it just plain works. I love the font preview features, and the program is super speedy compared to Apple's default Font Book, which grinds to a halt with more than a couple hundred fonts. I'm really enjoying rediscovering my fonts.
Adobe Illustrator seems a bit sluggish when FontExplorer is running. Aside from that my only complaint is that they need some more foundries in their store—I can imagine this will change quickly.